First published online: 22 Jun 2016
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Int J Basic Sci Med. 2016;1(1):4-7.
doi: 10.15171/ijbsm.2016.02
  Abstract View: 278
  PDF Download: 347
  Full Text View: 334

Original article

TTG IgA in Functional Constipation: Is It Rational to Be Evaluated?

Iraj Shahramian 1, Mahmood Haghighat 2, Noor Mohammad Noori 3 * , Ali Reza Teimouri 3, Elham Sharafi 3, Manijeh Kalili 3, Maryam Ataollahi 2, Maryam Bahmanyar 2

1 Department of Pediatric, Zabol University of Medical Sciences, Zabol, Iran
2 Department of Pediatric Gastroentrology, Shiraz University of Medical Sciences, Shiraz, Iran
3 Children and Adolescents Health Research Center, Zahedan Medical University, Zahedan, Iran
*Correspondence to: Noor Mohammad Noori, MD; Children and Adolescents Health Research Center, Zahedan Medical University, Zahedan, Iran. Email: dr_noori_cardio@yahoo.com

Abstract

Background: It is suggested that constipation could be due to celiac disease (CD); therefore, this study aimed to determine the prevalence of positive tissue transglutaminase (tTG) IgA test among children with functional constipation (FC).

Methods: In this case-control study, 182 consecutive patients with FC who fulfilled the Rome III criteria as cases were compared with 240 healthy children as the control group in terms of suspicious CD by measuring the serum tTG IgA level.

Results: There was a significant difference in favor of the case group in terms of serum tTG IgA levels (P = 0.000). The probability of having CD would change based on belonging to each group (case/control odds ratio [OR] = 0.222).

Conclusion: With respect to these data, tTG IgA level was observed to be significantly higher in patients relative to healthy children; therefore, it is recommended that patients be screened for CD through the tTG IgA.

Please cite this article as follows: Shahramian I, Haghighat M, Noori NM, et al. TTG IgA in functional constipation: is it rational to be evaluated? Int J Basic Sci Med. 2016;1(1):4-7. doi:10.15171/ijbms.2016.02.
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