Submitted: 04 Jul 2016
Revised: 17 Aug 2016
Accepted: 21 Aug 2016
First published online: 27 Sep 2016
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Int J Basic Sci Med. 2016;1(2):48-52.
doi: 10.15171/ijbsm.2016.11
  Abstract View: 285
  PDF Download: 308
  Full Text View: 262

Review article

Micro-RNAs and Their Roles in Breast Cancer Pathogenesis; An Updated Review Article

Mohammad Hossein Bakhshi Aliabad 1, Shahnaz Kheirandish 1, Zeynab Zarezadeh 1, Nasim Saeidi 1, Hamid Kabiri 1, Zahra Khazaei 1, Hossein Sahamifar 1, Fatemeh Taghvaei 1, Sepideh Jafarzadeh 1, Masoud Zare 1, Sajad Bahrami-Babaheidar 1, Mahta Mazaheri 2 *

1 MSc, Student of Genetics, Faculty of Medecine, Shahid Sadoughi University of Medical Sciences, International Campus, Yazd, Iran
2 Associate Professor of Medical Genetics, Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Micro-RNAs (miRNAs) are small molecules that modulate the translation of target mRNA through binding to these molecules. In cancer, the expression of oncogenes and suppressors are increased and decreased, respectively. MiRNAs are one of the causing factors in the formation of cancer. To collect data, research articles in PubMed and Google Scholar were searched under keywords including breast cancer and micro-RNA. The data obtained from articles published in prestigious journals showed that some miRNAs are involved in the suppression and some in the induction of cancer cell growth in breast cancer tissue. Some of them are also involved in the aggression and metastasis. According to the obtained results, it seems that assessing miRNAs in breast cancer tissue can be considered as a potential candidate for prognosis and may be used in pre-diagnosis of the disease in near future.
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