Submitted: 27 Nov 2017
Accepted: 08 Mar 2018
First published online: 30 Sep 2018
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Int J Basic Sci Med. 2018;3(3):109-113.
doi: 10.15171/ijbsm.2018.20
  Abstract View: 148
  PDF Download: 174

Original article

Acute and Recovery Changes of TNF-α and IL-1β in Response to Aerobic Exercise in Smokers and Nonsmokers

Mohammad Ali Seyed Hoseini 1, Mojtaba Eizadi 2 * ORCiD, Ashraf Amini 3, Zahra Mirakhori 3

1 Department of Physical Education and Sport Sciences, Parand Branch, Islamic Azad University, Tehran, Iran
2 Department of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran
3 Department of Physical Education and Sport Sciences, Amirkabir University of Technology, Tehran, Iran

Abstract

Introduction: Recent evidence has shown that acute exercise affects the immune response in healthy individuals. However, the effect of aerobic exercise on inflammatory markers in smokers has not been well studied. This study evaluated acute and recovery responses of inflammatory cytokines to moderate aerobic exercise in male smokers.

Methods: For this purpose, 15 sedentary male smokers and 15 male non-smokers matched for age and body mass index (BMI) performed aerobic exercise involving 40-minute running at 70% of maximum heart rate (HRmax). Blood samples were obtained pre-exercise (baseline), immediately post exercise (zero), as well as 60 minutes and 24 hours after exercise for analysis of interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels. The data were analyzed using SPSS 16.0 and one-way analysis variance (ANOVA) with repeated measures.

Results: No differences were observed for baseline IL-1β between smokers and non-smokers. However, serum TNF-α level was significantly higher in smokers (75.1 ± 14.3) than in nonsmokers (37.2 ± 9.11) at baseline (P=0.01). Aerobic exercise significantly reduced TNF-α level immediately after exercise (58.9 ± 11.6), and at 60 minutes (50.1 ± 14.8), and 24 hours (53.44 ± 12.3) post exercise in comparison with baseline (P=0.02) in smokers. TNF-α levels remained significantly higher in smokers compared to non-smokers immediately, 60 minutes, and 24 hours post exercise. IL-1β levels revealed no significant differences between smokers and nonsmokers at baseline, immediately, 60 minutes, and 24 hours post exercise. Furthermore, exercise did not significantly affect acute or recovery changes of TNF-α and IL-1β in non-smokers.

Conclusion: In conclusion, based on acute and recovery responses of serum TNF-α to exercise, it seems that a moderate aerobic exercise may reveal beneficial effects on inflammatory profile in smokers.

Please cite this article as follows: Seyed Hoseini MA, Eizadi M, Amini A, Mirakhori Z. Acute and recovery changes of TNF-α and IL-1β in response to aerobic exercise in smokers and non-smokers. Int J Basic Sci Med. 2018;3(3):109- 113. doi:10.15171/ ijbms.2018.20.
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