Submitted: 22 Jan 2018
Accepted: 15 Mar 2018
First published online: 30 Jun 2018
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Int J Basic Sci Med. 2018;3(2):89-93.
doi: 10.15171/ijbsm.2018.16
  Abstract View: 154
  PDF Download: 190

Original article

Adipokine Omentin-1: A Diagnostic Tool in Breast Cancer

Parisa Nourbakhsh 1, 2, Ali Ganji 1, 2 ORCiD, Iman Farahani 1 * , Rezvan Hosseinian 3, Fatemeh Yeganefard 1, Rezvan Mirzaee 1 ORCiD, Ghasem Mosayebi 1, 2 *

1 Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
2 Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
3 Department of Radiation and Oncology, Khansari Hospital, Arak University of Medical Sciences, Arak, Iran

Abstract

Introduction: Breast cancer is the most frequent solid malignancy in women. Omentin-1 is synthesized by visceral adipose tissue, placenta, and ovary and its production is altered in some cancers. The aim of this study was to assess omentin-1 as a diagnostic marker in patients with breast cancer.

Methods: The participants of the study included 90 women (45 patients with breast cancer and 45 healthy women as control group). In addition to anthropometric and blood parameters analysis, omentin-1 serum levels were measured by enzyme-linked immunosorbent assays method. Receiver operator characteristic curve and positive and negative predictive values (PPV and NPV) were calculated to define diagnostic accuracy.

Results: Serum omentin-1 level in breast cancer patients (157 ng/L ± 66 ng/L, mean ± SD) was significantly lower than that of the control group (217 ng/L±75 ng/L, mean ± SD). There was no significant correlation between omentin-1 levels and anthropometric and blood parameters. The best cut-off point for the diagnosis of breast cancer was at 146 ng/L. The sensitivity and specificity for omentin-1 with 95% CI (0.611 to 0.837) were 60% and 85%, respectively. Calculated PPV and NPV at the 146 ng/L cut-off point were 88.8% and 51.5%, respectively.

Conclusion: Breast cancer patients had significantly lower serum level of omentin-1 than healthy women. Omentin-1 may be beneficial as a screening test along with the early-approved methods in the diagnosis of patients with breast cancer.

Please cite this article as follows: Nourbakhsh P, Ganji A, Farahani I, et al. Adipokine omentin-1: a diagnostic tool in breast cancer. Int J Basic Sci Med. 2018;3(2):89- 93. doi:10.15171/ ijbms.2018.16.
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