Submitted: 25 Apr 2018
Accepted: 02 Jun 2018
First published online: 30 Sep 2018
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Int J Basic Sci Med. 2018;3(3):120-126.
  Abstract View: 13
  PDF Download: 15

Original article

An Investigation on the Pharmacological Profile of Titanium (IV) and Aluminum (III) 8-Hydroxyquinoline Derivatives Grafted on MCM-41 Mesoporous Silica 

Abstract

8-hydroxyquinoline and 5-chloro-8-hydroxyquinoline were treated with a titanium (IV) and Aluminum (III) alkoxide reagents to generate (Q)2(2-BuO) Al (Q = 8-hydroxyquinoline and 5-chloro-8-hydroxyquinoline) and (Q)2(O-iPr)2Ti (Q = 5-chloro-8-hydroxyquinoline) complexes. These active complexes underwent successive grafting on MCM-41 mesoporous silica in order to improve overall toxicity and stability of them. The prepared nanocomposites were characterized. Anti-bacterial activity of the compounds on Escherchia coli (ATCC 1330), Salmonella typhi (PTCC 1609) and Staphylococcus aureus subsp. Areas (PTCC 1113) were tested and the anti-fungal activity of them was determined using the agar well diffusion assay method on SCC (for yeasts) and Muller Hinton Agar medium (for filamentous fungi). The results showed that the anti-microbial (bacterium and fungi) effect of the Ti & Al complexes can be improved in the solid-state using appropriate chlorine substituent on the 8-hydroxyquinoline ligand and grafting to the mesoporous silica.
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