Submitted: 25 Sep 2016
Revised: 08 Nov 2016
Accepted: 08 Nov 2016
First published online: 24 Nov 2016
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Int J Basic Sci Med. 2016;1(2):40-47.
doi: 10.15171/ijbsm.2016.10
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Review article

Cross-talk between the Immune System and Tuberculosis Pathogenesis; a Review with Emphasis on the Immune Based Treatment

Mohammad Reza Javan 1, Ahmad ali Jalali nezhad 2, Sarieh Shahraki 2, Amin Safa 1, Halimeh Aali 3 * , Zohre Kiani 4

1 Department of Immunology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
2 Department of Physiology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
3 Department of Internal Medicine, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
4 Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran


As a globally major health problem, tuberculosis (TB) causes almost two million cases of death annually. Epidemiological studies demonstrate that a third of the world’s individuals is infected with Mycobacterium tuberculosis. Approximately 10% of infected patients with M. tuberculosis develop chronic manifestation as TB. Due to HIV coinfection and emerging the drug-resistant TB, the disease has been increasing and its control has been frustrated in several parts of the world.Current diagnostic techniques and therapeutic tools for TB are not satisfactory. Consequently, it is urgently essential to establish new therapies concerning vaccines, immunotherapeutic agents to provide prosperous attempts for TB controlling. To achieve this goal, it is required to be armed with comprehensive understanding of immunobiology and immunopathogenesis of TB. This would be beneficial in designing new immune-based protections, drug discoveries, personalized medicine by choosing highly-effective immunotherapeutic interventions, identification and development of novel drug candidates. Hopefully, immunotherapies could be advantageous in modulating the immune system in patients with TB, providing efficient control of M. tuberculosis infection perpetuation and, therefore, its pathogenesis. This review herein attempts to describe the function of immune system in response to TB that is of the therapeutical and clinical importance. Moreover, new insights based on therapeutics to resolve TB with immunological orientation will be discussed.
Please cite this article as follows: Javan MR, Jalali Nezhad AA, Shahraki S, Safa A, Aali H, Kiani Z. Cross-Talk between the immune system and tuberculosis pathogenesis; a review with emphasis on the immune based treatment. Int J Basic Sci Med. 2016;1(2):40-47. doi:10.15171/ijbms.2016.10.
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