Submitted: 01 Aug 2016
Revised: 02 Oct 2016
Accepted: 02 Oct 2016
First published online: 08 Oct 2016
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Int J Basic Sci Med. 2016;1(2):58-62.
doi: 10.15171/ijbsm.2016.13
  Abstract View: 622
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Original article

Comparison of the Serum Levels of Interferon-α in the Patients With Crimean-Congo Hemorrhagic Fever Based on Disease Severity

Maliheh Metanat 1, Masoud Salehi 1, Anita Ale Nabi 1, Masoume Noori Jangi 1 * , Alireza Noori Jangi 2, Mehdi Noori Jangi 3, Nahid Sepehri Rad 1, Farshid Fathi 4

1 Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
2 Veterinary Medicine, Zabol University, Zabol, Iran
3 Internal Assistant, Department of Hematology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


Introduction: Crimean-Congo hemorrhagic fever (CCHF) is an acute viral and potentially fatal disease that is endemic in the south east of Iran, especially Sistan and Baluchestan. This study aimed to measure the serum levels of interferon-[1]r (IFN-[1]r) in the patients with CCHF, considering the disseminated intravascular coagulation (DIC) severity. The second aim was to determine the correlation between the serum levels of IFN-[1]r and DIC severity using the guidance of diagnosis and treatment of the CCHF. Methods: Thirty-seven patients with CCHF were studied. The diagnosis was made, based on the detection of viral RNA by real time-polymerase chain reaction (RT-PCR) and by positive serology. These patients, based on the severity of DIC, were divided into two groups. The serum levels of IFN-[1]r were measured by the enzyme-linked immunosorbent assay (ELISA) method and compared between these two groups. Data analysis was performed using the SPSS 20.0 and non-parametric statistical tests were used for analyses. Results: The mean serum levels of IFN-[1]r were lower in the patients with CCHF on the ­rst day compared to the ­fth day of admission (P < 0.008). There was a signi­cant relationship between the serum levels of IFN-[1]r and DIC severity, as the level of IFN-[1]r was lower in the patients with overt DIC (P < 0.001). The serum level of IFN-[1]r in the patients with the overt DIC was 1.04 pg/dL with 90% speci­city and 88% sensitivity. Conclusion: The serum levels of IFN-[1]r were lower in the patients with severe CCHF, and their evaluation may be used as a marker for the diagnosis of disease severity.
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