Submitted: 25 Nov 2018
Revised: 06 Feb 2019
Accepted: 23 Feb 2019
First published online: 20 Mar 2020
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Int J Basic Sci Med. 2019;4(4):155-162.
doi: 10.34172/ijbsm.2019.06
  Abstract View: 18
  PDF Download: 19

Original article

Tris (2-aminoethyl) Amine Functionalized Nanoporous Silica SBA-15 as a Potential Drug Carrier for Citalopram

Fatemeh Dalayi 1, Leila Hajiaghababaei 1 * , Alireza Badiei 2, Elham Boorboor Azimi 2, Mohammad Reza Ganjali 3, Ghodsi Mohammadi Ziarani 4

1 Department of Chemistry, Yadegar-e-Imam Khomeini (RAH) Shahre Rey Branch, Islamic Azad University, Tehran, Iran
2 School of Chemistry, College of Science, University of Tehran, Tehran, Iran
3 Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran
4 Department of Chemistry, Alzahra University, Tehran, Iran

Abstract

Introduction: Ordered nanoporous silica such as SBA-15 has a great potential for application in controlled drug release systems. Chemical modification of the silanol groups of SBA-15 allows better control over drug loading and release. Therefore, tris(2-aminoethyl) amine-functionalized mesoporous silica SBA-15 was evaluated as a potential carrier for the delivery of citalopram. Methods: Tris (2-aminoethyl) amine-functionalized SBA-15 was synthesized and characterized by various methods. Citalopram was loaded on the functionalized SBA-15 and drug release into simulated body fluid (SBF) solution and phosphate buffers was investigated.Results: The optimal condition for loading of the citalopram was obtained at pH = 9 after stirring for 5 minutes. The release profile of citalopram was monitored in phosphate buffers with three different pH values of 5, 7, and 8. A faster release rate at lower pH value was observed, suggesting a weaker interaction because of the protonation of the amino group of the functionalized SBA-15. The average release rate of citalopram from each gram of functionalized SBA-15 was 12 µg h-1 in the SBF. Conclusion: The results showed that loading amount and release rate of citalopram depended on pH value and the release process showed a very slow release pattern. Therefore, tris (2-aminoethyl) amine-functionalized SBA-15 is a suitable carrier for controlled release of citalopram and has a great potential for disease therapy.
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