Submitted: 30 Dec 2018
Accepted: 13 Jul 2019
First published online: 30 Jun 2020
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Int J Basic Sci Med. 2020;5(2):39-42.
doi: 10.34172/ijbsm.2020.08
  Abstract View: 25
  PDF Download: 24

Brief report

Homo Sapiens (Human) microRNA 187 Expression Is Dysregulated in Testis of Non-obstructive Azoospermic Men

Fahimeh Piryaei 1, 2, Hossein Mozdarani 1 * ORCiD, Mohammad Ali Sadighi Gilani 3 ORCiD, Mansour Ebrahimi 4 ORCiD

1 Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2 Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
4 Department of Biology, School of Basic Sciences, Qom University, Qom, Iran
*Correspondence to Hossein Mozdarani, Email: Email: Mozdarah@modares.ac.ir

Abstract

Introduction: MiRNA expression alterations are closely related to growth, proliferation, and cell development. In addition, miR-187 has been found to regulate cellular proliferation. Further, spermatogenesis is a highly complicated process which is regulated through several genes targeted by miRNAs. However, no study has completely addressed the etiology of spermatogenic impairments. Accordingly, the present study examined the expression pattern of Homo sapiens (human) microRNA (hsa-mir-187) in the testicular biopsies of infertile men with non-obstructive azoospermia (NOA) and Sertoli cell-only syndrome (SCOS) subtype in comparison with those with obstructive azoospermia (OA).

Methods: Quantitative reverse‐transcription polymerase chain reaction analysis was performed to assess the expression level of hsa-mir-187 using the ΔΔCt method.

Results: Our data indicated that hsa-mir-187 was significantly up-regulated in the testis of the SCOS group (P˂ 0.05) in comparison with the OA group.

Conclusion: In general, the findings suggest that the differential expression of hsa-mir-187 is linked with male infertility and shed more light on molecular defects that underlie spermatogenic impairments.

Please cite this articleas follows: Piryaei F,Mozdarani H, SadighiGilani MA, EbrahimiM, Homo Sapiens(Human) microRNA187Expression IsDysregulated in Testisof Non-obstructiveAzoospermic Men.Int J Basic Sci Med.2020;5(2):39-42. doi:10.34172/ijbms.2020.08.
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