Submitted: 05 Jul 2019
Accepted: 18 Dec 2019
First published online: 30 Jun 2020
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Int J Basic Sci Med. 2020;5(2):54-60.
doi: 10.34172/ijbsm.2020.11
  Abstract View: 31
  PDF Download: 29

Original article

Antinociceptive and Anti-inflammatory Effects of Methanolic Extract of Laurencia caspica

Katayoon Karimzadeh 1 * , Mahdiyeh Ramzanpoor 1, Shadi Keihankhadiv 2

1 Department of Biology, Lahijan Branch, Islamic Azad University, Lahijan, Iran
2 Department of Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
*Correspondence to Katayoon Karimzadeh, Email: Email: karimzadehkathy@yahoo. co.uk

Abstract

Introduction: Seaweeds are valuable resources for the discovery of efficient and safe drugs for pain treatment. In the present investigation, we evaluated the antinociceptive and anti-inflammatory properties of, methanolic extract of Laurencia caspica, a red algae, in mice models.

Methods: The analgesic effect of methanolic extract of L. caspica was assessed by hot-plate and acetic acid-induced writhing tests in male Swiss albino mice (weight = 20-25 g). The anti-inflammatory activity of methanolic extract of L. caspica was also evaluated by formalin-induced ear edema and xylene-induced paw edema tests.

Results: The total flavonoid content of the extract was estimated as 0.0537 mg quercetin/g extract. Both first and second phases of the nociception were significantly inhibited at a dose of 120 mg/kg of methanolic extract of L. caspica. The observed anti-inflammatory effect was dose-dependent. Acetic acid-induced writhing test and hot plate test showed that the extract significantly reduced pain in all evaluated doses (15, 30, 60, and 120 mg/kg). The antinociceptive activity of the methanolic extract was significantly reduced by naloxone (4 mg/kg). Moreover, the extract significantly reduced paw edema at the dose of 120 mg/kg in all the animals.

Conclusion: Methanolic extract of L. caspica exhibited central analgesic effect, as well as anti-inflammatory activity probably due to the presence of constituents like flavonoids and triterpenoids.

Please cite this article as follows: Karimzadeh K, Ramzanpoor M, Keihankhadiv S. Antinociceptive and Anti-inflammatory Effects of Methanolic Extract of Laurencia caspica. Int J Basic Sci Med. 2020;5(2):54- 60. doi:10.34172/ ijbms.2020.11.
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