Submitted: 20 Aug 2020
Revised: 21 Sep 2020
Accepted: 12 Oct 2020
First published online: 24 Dec 2020
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Int J Basic Sci Med. 2020;5(3):68-84.
doi: 10.34172/ijbsm.2020.14
  Abstract View: 25
  PDF Download: 34

Review article

Probiotics: An Update to Past Researches

Reza Shirazinia 1, Ali Akbar Golabchifar 1 * , Abolfazl Panahi Mishkar 2, Mohammad Reza Fazeli 3

1 Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
2 Human Ecology, Kerman University of Medical Sciences, Kerman, Iran
3 Pharmaceutical Quality Assurance Research Center, The institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran


Probiotics are beneficial bacteria living in the microbiota ecosystem of the human body playing particular important roles in human health. The increasing rate of various diseases and the studies about the balance of gut microbiome made scientists trying to find novel therapies in this regard and hypothesize the relationships between the imbalance of gut microbiome and spread of various diseases especially in the immune system. Previous studies have indicated that when administrated in specific amounts, probiotics exert beneficial properties for human health such as antibacterial effects, cytotoxic effects, Hypocholesterolemic effects, immunomodulatory effects, wound healing effects etc. Probiotics also are known to produce nourishing healthy supplements for the human body such as vitamin K and B as well as healthy fatty acids. In this regard summarization of scientific evidence may help to familiarize the scientists with this novel area of research helping to find effective therapies for various disease. In this study, we used published literature in scientific databases such as Web of Science, Cochrane Library, Medline, PubMed, Science Direct, Scopus, as well as Google Scholar for data collection. So, the present review describes scientific-based evidence about probiotics and some of their beneficial effects to highlight the path for further researches about these beneficial bacteria.
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