Submitted: 22 May 2017
Accepted: 18 Sep 2017
First published online: 30 Sep 2017
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)

Int J Basic Sci Med. 2017;2(3):151-156.
doi: 10.15171/ijbsm.2017.28
  Abstract View: 399
  PDF Download: 583
  Full Text View: 303

Original article

The Long-term Effects of Colostrum Supplementation and Sprint-Endurance Training on Plasma VEGF Levels in Male Wistar Rats

Maryam Barahooee Khajeahmad 1, Mehdi Mogharnasi 2 * , Abbas Salehikia 3, Mohsen Foadoddini 4, Javad Bayat 5

1 MSc Student in Exercise Physiology, Department of Sport Sciences, University of Sistan and Baluchestan, Zahedan, Iran
2 Associate Professor in Exercise Physiology, Department of Sport Sciences, University of Birjand,Birjand, Iran
3 Assistant Professor, Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran
4 Associate Professor in Physiology, Atherosclerosis and Coronary Artery Research Center, Department of Physiology, Birjand University of Medical Sciences, Birjand, Iran
5 Master in Exercise Physiology, Department of Sport Sciences, University of Sistan and Baluchestan, Zahedan, Iran

Abstract

Introduction: Bovine colostrum is an antioxidant material, however, its potential impact along with various methods of physical exercise on changes in vascular endothelial growth factor (VEGF)is unclear. The aim of this study was to evaluate the long-term effects of colostrum supplementation and sprint-endurance training on plasma VEGF levels in male Wistar rats.

Methods: In our study, 48 male Wistar rats were used. The rats were assigned into 6 groups (control, colostrum supplementation, aerobic exercise, anaerobic exercise, colostrum supplementation-aerobic exercise, and colostrum supplementation-anaerobic exercise). Groups receiving colostrum were orally administrated 300 mg/kg/d bovine colostrum for 10 weeks. Training groups received sprint-endurance training, 3 times a week for a period of 10 weeks, with specified intensity and duration. In all the groups, blood samples were taken in the morning on an empty stomach 24 hours after the last training session. Data were analyzed using SPSS version 19 software and the Kolmogorov-Smirnov (K-S), one-way analysis of variance (ANOVA), and Tukey tests at α <0.05.

Results: The findings showed that colostrum supplementation for 10 weeks with dose of 300 mg/kg significantly increased VEGF levels in all the study groups compared to the control group receiving normal saline (P<0.05). Moreover, colostrum supplementation along with sprintendurance training increased VEGF levels more effectively compared to other groups receiving sprint-endurance training along with normal saline.

Conclusion: The findings indicated that intake of colostrum, as a strong antioxidant supplement having enzymatic and non-enzymatic antioxidants, along with sprint-endurance training for 10 weeks increased plasma VEGF levels, thereby playing a possible significant role in vascular angiogenesis.

Please cite this article as follows: Barahooee Khajeahmad M, Mogharnasi M, Salehikia A, Foadoddini M, Bayat J. The long-term effects of colostrum supplementation and sprint-endurance training on plasma VEGF levels in male Wistar rats. Int J Basic Sci Med. 2017;2(3):151- 156. doi:10.15171/ ijbms.2017.28.
First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 399

Your browser does not support the canvas element.


PDF Downloaded: 583

Your browser does not support the canvas element.


Full Text Viewed: 303

Your browser does not support the canvas element.