Submitted: 09 May 2017
Accepted: 24 Sep 2017
First published online: 30 Sep 2017
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Int J Basic Sci Med. 2017;2(3):113-122.
doi: 10.15171/ijbsm.2017.22
  Abstract View: 541
  PDF Download: 516
  Full Text View: 464

Review article

Molecular and Biochemical Aspects of Hypophosphatemic Rickets: An Updated Review

Fateme Asadzadeh Manjili 1, Mohammad Hosein Bakhshi Aliabad 2, Seyed Mehdi Kalantar 3 * , Afsaneh Sahebzamani 4, Amin Safa 5

1 Department of Human Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Department of Human Genetics, Shahid Sadoughi University of Medical Sciences, International Campus, Yazd, Iran
3 Reproductive & Genetic Unit Recurrent Abortion Research Center, Yazd Reproductive Science Institute, Yazd University of Medical Sciences, Yazd, Iran
4 Pediatrician and Genetic Counselor, Kerman Welfare Organization, Kerman, Iran
5 Department of Immunology, Zabol University of Medical Sciences, Zabol, Iran


Rickets is associated with aberrant mineralization in growth plates leading to the deformity of bone structure. The two main types of rickets are phosphopenic and calcipenic rickets. Phosphopenic rickets is found in a variety of sorts; the most common is the X-linked dominant hypophosphatemic rickets (HR) caused by a mutation in PHEX gene. The FGF23, DMP1, and PHEX are among the most important genes in the etiology of HR disorder. The interaction of these genes is essential for proper bone mineralization. However, the underlying mechanism is not comprehensively known. For data collection, we searched the most recent articles in Science Direct, PubMed and Google Scholar using hypophosphatemia, mutation, PHEX and FGF23 as keywords. The search results revealed that most of the articles have mainly focused on various types of mutations causing hypophosphatemia in different populations. However, there was a lack of enough studies elucidating the interaction of genes involved in this disorder. This review mainly focuses on the various types of phosphopenic rickets and genetic mutations of various agents crucial for bone mineralization and how these mutations exert their effects on biochemical agents like vitamin D and parathyroid hormone (PTH) . It also reviews the available treatment and molecular techniques for managing this disorder.
Please cite this article as follows: Asadzadeh Manjili F, Bakhshi Aliabad MH, Kalantar SM, Sahebzamani A, Safa A. Molecular and biochemical aspects of hypophosphatemic rickets: an updated review. Int J Basic Sci Med. 2017;2(3):113- 122. doi:10.15171/ ijbms.2017.22.
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