Submitted: 10 Aug 2017
Accepted: 10 Oct 2017
First published online: 31 Dec 2017
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Int J Basic Sci Med. 2017;2(4):166-169.
doi: 10.15171/ijbsm.2017.31
  Abstract View: 335
  PDF Download: 418

Brief report

Evaluation of Antibacterial Activity of Iron Oxide Nanoparticles Against Escherichia coli

Mehrdad Khatami 1, 2, Mohammad Reza Aflatoonian 3 * , Hakim Azizi 4 * , Farideh Mosazade 1, Ahmad Hooshmand 1, Marcos Augustino Lima Nobre 5, Farzad Minab Poodineh 4, Mansour Khatami 3, Sam Khraazi 1, Hadi Mirzaeei 6

1 Nano Bioelectrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran
2 Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3 Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
4 Research Center for Tropical and Infectious Diseases, Zabol University of Medical Sciences, Zabol, Iran
5 Fac de Ciências e Tecnologia-FCT, Universidade Estadual Paulista-UNESP, Presidente Prudente-SP, 19060-900, Brazil
6 School of Medicine, Zabol University of Medical Sciences, Zabol, Iran

Abstract

Introduction: Considering the usefulness of metal oxide nanoparticles in biology and biomedicine, iron oxide nanoparticles were biosynthesized using bioresource engineering to evaluate its antibacterial activity against Escherichia coli.

Methods: Macrodilution method was used for calculating the lowest concentration which prevented the growth of bacteria (minimum inhibitory concentration [MIC]), and the lowest concentration that destroyed all bacterial cells (minimum bactericidal concentration [MBC]).

Results: The lowest concentration of iron oxide nanoparticles that inhibited the growth of E. coli (MIC) was recorded at 250 µg/mL. On the other hand, the MBC of iron oxide nanoparticles was calculated at 500 µg/mL.

Conclusion: Iron oxide nanoparticles were produced by a green and eco-friendly, simple and inexpensive method. The results showed the inhibitory effect of iron oxide nanoparticles on E. coli at 250 µg/mL. This may suggest using these nanoparticles as potential antibacterial agents.

Please cite this article as follows: Khatami M, Aflatoonian MR, Hakim Azizi H, et al. Evaluation of antibacterial activity of iron oxide nanoparticles against Escherichia coli. Int J Basic Sci Med. 2017;2(4):166- 169. doi:10.15171/ ijbms.2017.31.
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