Submitted: 30 Dec 2017
Revised: 17 Feb 2020
Accepted: 04 Jun 2021
First published online: 24 Jun 2021
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Int J Basic Sci Med. 2021;6(2):69-73.
doi: 10.34172/ijbsm.2021.12
  Abstract View: 138
  PDF Download: 124

Original Article

Serum Interleukin-17 Alterations in Patients With Chronic Kidney Disease Undergoing Eight Weeks of Aerobic Training

Arman Jalili 1, Ali Asghar Ravasi 2, Sirous Choobineh 2, Ali Alidadi 3, Rahman Suri 2, Hosseinali Khazaei 4 *

1 Alborz Campusm, Tehran University, Tehran, Iran
2 Faculty of Physical Education and Sport Sciences, Tehran University, Tehran, Iran
3 Department of Nephrology, Zahedan University of Medical Sciences, Zahedan, Iran
4 Clinical Immunology Research Center, Department of immunology and hematology, Zahedan University of Medical Sciences, Zahedan, Iran


Introduction: Regular physical activities may have effect on the course of chronic kidney disease (CKD). Here, we aimed to ascertain the changes of serum interleukin-17 (IL-17) following eight weeks of aerobic training in CKD patients. Methods: The CKD patients referred to Zahedan Edalat Clinic and Ali-Ibn Abi Talib hospital in Zahedan city (Iran) were enrolled. Sixty patients aged between 30 and 50 years old were chosen by a random method and assigned into the control and intervention groups (each group constituted 30 people). In this study, aerobic exercises were performed at 50%–80% of the maximal heart rate. Peripheral blood was obtained one day before the beginning of exercise and one day after the end of the intervention. Serum IL-17 level was quantified using a commercial specific ELISA kit. Results: The mean values of IL-17 in CKD patients before and after 8 weeks of aerobic exercise were 1.67 ± 0.403 pg/mL and 1.58 ± 0.170 pg/mL in the intervention group (P value= 0.039) whereas the mean values of IL-17 in the control group before and after the intervention were 1.31 ± 0.529 pg/mL and 1.35 ± 0.505 pg/mL (P value= 0.794).Conclusion: Eight weeks of aerobic training can significantly reduce serum IL-17, an inflammatory marker, in CKD patients.
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