Submitted: 23 Dec 2017
Accepted: 24 Feb 2018
First published online: 31 Mar 2018
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Int J Basic Sci Med. 2018;3(1):1-8.
doi: 10.15171/ijbsm.2018.01
  Abstract View: 198
  PDF Download: 241

Review article

Juxtaposition of Coeliac Disease and Type 1 Diabetes; the Role of Shared Non-human Leukocyte Antigen Loci

Iraj Shahramian 1 ORCiD, Hossein Shahdadi 2, Ali Bazi 3, 4 * ORCiD, Nosratollah Masinaeinejad 3, Mojtaba Delaramnasab 3, 4

1 Pediatric Ward, Amir-Al-Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran
2 Faculty of Nursing, Zabol University of Medical Sciences, Zabol, Iran
3 Faculty of Allied Medical Sciences, Zabol University of Medical Sciences, Zabol, Iran
4 Clinical Research Development Unit, Amir-Al-Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran


Although extensive studies have been performed to explore the role of various alleles within the human leukocyte antigen (HLA) in susceptibility to coeliac disease (CD) and type 1 diabetes (T1D), less attention has been dedicated to the role of shred non-HLA loci. In the present report, we have provided a review on the role of genetic variants in seven shared non-HLA loci in determining the risk of either CD or T1D. The literature search was done on the Web of Knowledge, PubMed, and Scopus databases using keywords of polymorphism, coeliac disease, and type 1 diabetes. The literature published within 2000-2017 were recruited. Seven discussed shared loci between CD and T1D were those resided within cytotoxic T-lymphocyte associated protein 4 (CTL4), regulator of G protein signaling (RGS1), SH2B adaptor protein (SH2B3), T cell activation Rho GTPase activating protein (TAGAP), interleukin 18 receptor accessory protein (IL18RAP), protein tyrosine phosphatase, non-receptor type (PTPN2), and C-C motif chemokine receptor (CCR5). The interaction between polymorphisms of these genes seems to exert a substantial impact on determining the risk of CD and T1D in context of each other. Polymorphisms residing in these loci can exert synergistic or opposing effects toward either protection or predisposition to CD and T1D. The majority of these polymorphisms affect the function of cytokine signaling or T cell activating pathways. The net outcome deems to be delineated by a complex interaction between these adaptor arms, as well as the modulatory effects of other components of immune system, in particular, HLA alleles.
Please cite this article as follows: Shahramian I, Shahdadi H, Bazi A, Masinaeinezhad N, Delaramnasab M. Juxtaposition of coeliac disease and type 1 diabetes; the role of shared non-human leukocyte antigen loci. Int J Basic Sci Med. 2018;3(1):1- 8. doi:10.15171/ ijbms.2018.01.
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