Submitted: 26 May 2018
Accepted: 18 Nov 2018
First published online: 31 Mar 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)

Int J Basic Sci Med. 2019;4(1):10-16.
doi: 10.15171/ijbsm.2019.03
  Abstract View: 116
  PDF Download: 138

Original article

The Effect of Methylphenidate and Aerobic Exercise on Renal Function of Male Rats

Ali Sepehrian 1 * ORCiD, Nader Shakeri 2, Hosein Abednatanzi 2, Shahram Soheili 3

1 Ph.D. Student of Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 Department of Physical Education and Sport Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran

Abstract

Introduction: Inadequate awareness and knowledge exists regarding the effects of stimulant drugs on renal health among athletes. The present study aimed to determine the effects of methylphenidate, as a stimulant drug, and aerobic exercise on renal function in rats.

Materials and Methods: Eighty male rats were randomly divided into 8 groups (n=10 per group) including control (Co), aerobic exercise sham (AE Sh), drug sham (D Sh), aerobic exercise (AE), the effective dose of drug (ED, 10 mg/kg), 3 times of effective dose (TED, 30 mg/kg), aerobic exercise-effective dose (AE-ED), and aerobic exercise-three times of effective dose (AE-TED). The drug was orally administrated to the animals, and then they were placed on a rat treadmill after 30 minutes. The physical activity (25 m/min) was performed 30 minutes a day, 3 days a week for two months. Twenty-four hours after the last session of AE, blood samples were taken from the rats and serum creatinine (Cr) and blood urea nitrogen (BUN) were determined.

Results: The results showed that serum Cr and BUN levels were not significantly different in the exercise group compared to the control groups (i.e., Co, AE Sham, and D Sham). However, serum BUN and Cr significantly increased in the AE-ED and AE-TED groups compared to the AE group (PCr=0.001 and PBUN=0.001).

Conclusion: In general, significant increases in the serum BUN and Cr levels in rats received methylphenidate indicated decreased renal function in these animals.

Please cite this article as follows: Sepehrian A, Shakeri N, Abednatanzi H, Soheili S. The effect of methylphenidate and aerobic exercise on renal function of male rats. Int J Basic Sci Med. 2019;4(1):10- 16. doi:10.15171/ ijbms.2019.03.
First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 116

Your browser does not support the canvas element.


PDF Downloaded: 138

Your browser does not support the canvas element.