Submitted: 23 Jul 2016
Revision: 30 Aug 2016
Accepted: 30 Aug 2016
ePublished: 27 Sep 2016
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Int J Basic Sci Med. 2016;1: 37-39.
doi: 10.15171/ijbsm.2016.09
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Mini review

Cancer: Disease Caused by Alteration of Genes

Manzoor Ahmad Malik 1*, Zahra Sepehri 2, Zafar Amin Shah 1

1 Cancer Diagnostic and Research Center, Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Kashmir-190011, J&K, India
2 Department of Internal Medicine, Zabol University of Medical Sciences, Zabol, Iran
*Corresponding Author: Email: maliksgpgi@gmail.com


In normal cells when genetic defects occur, there are some sensitive mechanisms through which the defect might be repaired or apoptosis might be induced. However in tumor cells such mechanisms are not highly sensitive; therefore they cannot detect such abnormalities. This failure in detection and/or repair of the genetic abnormality results in the survival of abnormal cells. This survival is followed up with growth of the cells without normal control and ultimately leads to the rise of malignant clones in the body.  Pathways in which these malignant transformations occur, are increasingly being studied to ­final effective treatments for different carcinomas.
Keywords: Cancer, Tumor suppressor genes, Oncogenes and low penetrance genes
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