Mohammad Hossein Bakhshi Aliabad
1, Shahnaz Kheirandish
1, Zeynab Zarezadeh
1, Nasim Saeidi
1, Hamid Kabiri
1, Zahra Khazaei
1, Hossein Sahamifar
1, Fatemeh Taghvaei
1, Sepideh Jafarzadeh
1, Masoud Zare
1, Sajad Bahrami-Babaheidar
1, Mahta Mazaheri
2*1 MSc, Student of Genetics, Faculty of Medecine, Shahid Sadoughi University of Medical Sciences, International Campus, Yazd, Iran
2 Associate Professor of Medical Genetics, Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Micro-RNAs (miRNAs) are small molecules that modulate the
translation of target mRNA through binding to these molecules. In cancer, the
expression of oncogenes and suppressors are increased and decreased,
respectively. MiRNAs are one of the causing factors in the formation of cancer.
To collect data, research articles in PubMed and Google Scholar were searched
under keywords including breast cancer and micro-RNA. The data obtained from
articles published in prestigious journals showed that some miRNAs are involved
in the suppression and some in the induction of cancer cell growth in breast
cancer tissue. Some of them are also involved in the aggression and metastasis.
According to the obtained results, it seems that assessing miRNAs in breast
cancer tissue can be considered as a potential candidate for prognosis and may
be used in pre-diagnosis of the disease in near future.
Keywords: Breast cancer, Micro-RNA, Pathogenesis