Micro-RNAs (miRNAs) are small molecules that modulate the
translation of target mRNA through binding to these molecules. In cancer, the
expression of oncogenes and suppressors are increased and decreased,
respectively. MiRNAs are one of the causing factors in the formation of cancer.
To collect data, research articles in PubMed and Google Scholar were searched
under keywords including breast cancer and micro-RNA. The data obtained from
articles published in prestigious journals showed that some miRNAs are involved
in the suppression and some in the induction of cancer cell growth in breast
cancer tissue. Some of them are also involved in the aggression and metastasis.
According to the obtained results, it seems that assessing miRNAs in breast
cancer tissue can be considered as a potential candidate for prognosis and may
be used in pre-diagnosis of the disease in near future.
Keywords: Breast cancer, Micro-RNA, Pathogenesis