Soodabeh Khalkhali
1,2, Naheed Mojgani
31 Department of Microbiology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2 Department of Microbiology, Fars Research and Science Branch, Islamic Azad University, Fars, Iran
3 Department of Biotechnology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran
Abstract
Probiotics are a set of nonpathogenic microorganisms without virulence which inhibit pathogen
growth in animals. Enterococcus faecium has been introduced as a probiotic and its probiotic
characteristics have been evaluated in several investigations. Evidence suggests that probiotics
may modulate the immune system of the host to improve responses against pathogens. Thus,
this review aimed to present recent studies regarding the effects of the E. faecium probiotic strain
on the host immune responses. It seems that E. faecium AL41, CGMCC, NCIMB, SF68, Strain
26, JWS 833 and EF55 strains improve beneficially the immune responses of the host. However,
most studies have been performed on animal models, therefore, clinical trials on humans are
required to understand the beneficial mechanisms of E. faecium on the human immune system.
Keywords: Probiotics, Enterococcus faecium, Immune responses
Keywords: Probiotics, Enterococcus faecium, Immune responses