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Submitted: 05 Jul 2016
Revision: 08 Mar 2017
Accepted: 11 Mar 2017
ePublished: 18 Mar 2017
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Int J Basic Sci Med. 2017;2: 58-70.
doi: 10.15171/ijbsm.2017.12
  Abstract View: 2659
  PDF Download: 2511
  Full Text View: 2833

Review article

Evaluation of Mechanical Properties and Medical Applications of Polycaprolactone Small Diameter Artificial Blood Vessels

Mahnazsadat Mirbagheri 1,2,3, Davod Mohebbi-kalhori 1,2,4,5*, Nafiseh Jirofti 1,2,6*

1 Engineering Department, Faculty of Engineering, University of Sistan and Baluchestan, Zahedan, Iran
2 Biomedical Engineering Laboratory (Central Lab), University of Sistan and Baluchestan, Zahedan, Iran
3 Graduate Student, University of Sistan and Baluchestan, Zahedan, Iran
4 Nanotechnology Research Institute, University of Sistan and Baluchestan, Zahedan, Iran
5 Faculty of Chemical Engineering, University of Sistan and Baluchestan, Zahedan, Iran
6 Chemical engineering PhD Student, University of Sistan and Baluchestan, Zahedan, Iran
*Corresponding Authors: Email: davoodmk@eng.usb.ac.ir; Email: nafisejirofti@pgs.usb.ac.ir

Abstract

Increasing the cardiovascular diseases and decreasing the possibility of autograft surgery are important factors that cause the choice of artificial vascular graft as an alternative treatment method. In this regard, producing artificial grafts similar to natural vessels is an important purpose that has long been followed as a gold standard by many researchers worldwide. In addition, mechanical properties including strength, long patency, bio-compatibility and hydrophobicity are necessary properties to achieve ideal vascular grafts. Hence there are various factors such as polymer type and preparation methods, which contribute to suitable mechanical properties. The electrospinning as an optimized method on one side and biocompatible, degradable and semicrystalline polycaprolactone (PCL) on the other side are used for their acceptable mechanical properties to manufacture synthetic vessels. In this study, PCL vascular grafts have been reviewed and a wide range of parameters affecting the improvement of mechanical properties and their performance have been described along with clinical applications. Therefore, by investigating and comparing single and composite PCL vascular grafts, we achieved acceptable results in the field of cell growth and adhesion as well as implanting grafts in animals such as rat and rabbit. By reviewing other studies, it was revealed that synthetic composite vessels made of PCL and natural polymers such as collagen and chitosan and synthetic polymers such as polyurethane (PU) for long patency and acceptable cell adhesion have shown good clinical results.
Keywords: Vascular grafts (synthetic blood vessel), Tissue engineering, Clinical applications
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