Introduction: Bovine colostrum is an antioxidant material, however, its potential impact along
with various methods of physical exercise on changes in vascular endothelial growth factor
(VEGF)is unclear. The aim of this study was to evaluate the long-term effects of colostrum
supplementation and sprint-endurance training on plasma VEGF levels in male Wistar rats.
Methods: In our study, 48 male Wistar rats were used. The rats were assigned into 6 groups
(control, colostrum supplementation, aerobic exercise, anaerobic exercise, colostrum
supplementation-aerobic exercise, and colostrum supplementation-anaerobic exercise). Groups
receiving colostrum were orally administrated 300 mg/kg/d bovine colostrum for 10 weeks.
Training groups received sprint-endurance training, 3 times a week for a period of 10 weeks,
with specified intensity and duration. In all the groups, blood samples were taken in the morning
on an empty stomach 24 hours after the last training session. Data were analyzed using SPSS
version 19 software and the Kolmogorov-Smirnov (K-S), one-way analysis of variance (ANOVA),
and Tukey tests at α <0.05.
Results: The findings showed that colostrum supplementation for 10 weeks with dose of 300
mg/kg significantly increased VEGF levels in all the study groups compared to the control group
receiving normal saline (P<0.05). Moreover, colostrum supplementation along with sprintendurance training increased VEGF levels more effectively compared to other groups receiving
sprint-endurance training along with normal saline.
Conclusion: The findings indicated that intake of colostrum, as a strong antioxidant supplement
having enzymatic and non-enzymatic antioxidants, along with sprint-endurance training for
10 weeks increased plasma VEGF levels, thereby playing a possible significant role in vascular