Reza Shirazinia
1 
, Mahdi Afshari
2 , Ali Akbar Golabchifar
1* , Hosein Ali Arab
1 , Abolfazl Panahi Mishkar
31 Department of Comparative Bioscience, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
2 Department of Community Medicine, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
3 Human Ecology, Kerman University of Medical Sciences, Kerman, Iran
Abstract
The coronavirus disease 19 (COVID-19) outbreak in Wuhan, Hubei province, is a global health problem affecting about 212 countries around the world, highlighting the importance of the global recruitment of scientists to find a way for managing this burden. So far, many studies have been conducted to find a treatment for COVID-19, some of which indicated promising results. In this situation, gathering the previously published evidence may provide new hypotheses/ solutions in this regard. Based on the role of inflammation in COVID-19-related deaths, we attempted to find a rational relationship between Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling and COVID-19 and inform JAK/STAT signaling inhibitors as candidates to manage or even prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Therefore, it is hoped that the present study provides new clues about the relationship between JAK/STAT signaling and the SARS-CoV-2 infection to highlight the role of JAK/STAT inhibitors as a possible treatment for managing inflammatory situations observed in the SARS-CoV-2 infection.
Keywords: Inflammation, JAK/STAT pathway, COVID-19