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Submitted: 24 Jan 2021
Revision: 25 Jun 2021
Accepted: 04 Jul 2021
ePublished: 29 Sep 2022
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Int J Basic Sci Med. 2022;7: 98-103.
doi: 10.34172/ijbsm.2022.18
  Abstract View: 340
  PDF Download: 231

Review Article

Inflammation and JAK/STAT Signaling: New Clues for the Treatment of COVID-19

Reza Shirazinia 1 ORCID logo, Mahdi Afshari 2 ORCID logo, Ali Akbar Golabchifar 1* ORCID logo, Hosein Ali Arab 1 ORCID logo, Abolfazl Panahi Mishkar 3

1 Department of Comparative Bioscience, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
2 Department of Community Medicine, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
3 Human Ecology, Kerman University of Medical Sciences, Kerman, Iran
*Corresponding Author: Correspondence to Ali Akbar Golabchifar, Email: , Email: aliakbar.golabchifar@gmail.com

Abstract

The coronavirus disease 19 (COVID-19) outbreak in Wuhan, Hubei province, is a global health problem affecting about 212 countries around the world, highlighting the importance of the global recruitment of scientists to find a way for managing this burden. So far, many studies have been conducted to find a treatment for COVID-19, some of which indicated promising results. In this situation, gathering the previously published evidence may provide new hypotheses/ solutions in this regard. Based on the role of inflammation in COVID-19-related deaths, we attempted to find a rational relationship between Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling and COVID-19 and inform JAK/STAT signaling inhibitors as candidates to manage or even prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Therefore, it is hoped that the present study provides new clues about the relationship between JAK/STAT signaling and the SARS-CoV-2 infection to highlight the role of JAK/STAT inhibitors as a possible treatment for managing inflammatory situations observed in the SARS-CoV-2 infection.
Keywords: Inflammation, JAK/STAT pathway, COVID-19

Please cite this article as follows: Shirazinia R, Afshari M, Golabchifar AA, Arab HA, Panahi Mishkar A. Inflammation and JAK/STAT signaling: new clues for the treatment of COVID-19. Int J Basic Sci Med. 2022;7(3):98-103. doi:10.34172/ijbsm.2022.18.
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