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Submitted: 22 Aug 2021
Revision: 06 Sep 2021
Accepted: 24 Sep 2021
ePublished: 30 Dec 2021
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Int J Basic Sci Med. 2021;6: 132-138.
doi: 10.34172/ijbsm.2021.24
  Abstract View: 109
  PDF Download: 73

Original Article

Down Regulation of Chemerin and Resistin in Type II Diabetic Rats Treated With Silver Nanoparticles Synthetized Using Eryngium thyrsoideum Boiss Extract

Samad Poureskandar Souha ORCID logo, Fariba Mahmoudi* ORCID logo, Ezzat Noorizadeh ORCID logo, Alireza Panahi ORCID logo

1 Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
*Corresponding Author: *Correspondence to Fariba Mahmoudi, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran. Phone number: 09144190422. P. O. Box: 179. Email: , Email: f.mahmoudi@uma.ac.ir

Abstract

Introduction: Diabetes is related to the higher production of inflammatory markers such as chemerin and resistin. Hypoglycemic influences of Eryngium thyrsoideum Boiss and silver nanoparticles (SNPs) have been established. The present study investigated the impacts of chemically or biologically synthesized SNPs using E. thyrsoideum extract on chemerin and resistin gene expressions in type II diabetic rats.

Methods: Twenty male Wistar rats weighing 180-200 g were used. Type 2 diabetes was induced by nicotinamide and streptozotocin. Saline and 2.5 mg/kg chemically or biologically synthesized SNPs were injected to diabetic rats for two weeks. Five healthy rats received saline for two weeks. One day after the last injection, fasting blood samples were collected. Mean serum concentrations of glucose, creatinine, urea, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured by spectrophotometry. The gene expression of chemerin and resistin was determined by real-time polymerase chain reaction (PCR).

Results: Mean serum concentrations of glucose, urea, ALT, AST, and mean relative gene expression of chemerin and resistin remarkably decreased in the diabetic group receiving SNPs prepared by either the chemical method or using Eryngium extract compared to the diabetic control group. Serum creatinine concentration did not change significantly in the control diabetic or diabetic groups receiving SNPs prepared either chemically or using the Eryngium extract.

Conclusion: Chemically or green synthesized SNPs prevent liver hepatocyte damage. They reduced inflammatory factors via exerting hypoglycemic effects.

Keywords: Eryngium thyrsoideum, Silver nanoparticles, Chemerin, Resistin

Please cite this article as follows: Poureskandar Souha S, Mahmoudi F, Noorizadeh E, Panahi A. Down regulation of chemerin and resistin in type ii diabetic rats treated with silver nanoparticles synthetized using eryngium thyrsoideum boiss extract. Int J Basic Sci Med. 2021;6(4):132- 138. doi:10.34172/ ijbms.2021.24.
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