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Submitted: 12 Nov 2021
Revision: 21 Jan 2022
Accepted: 24 Jan 2022
ePublished: 25 Sep 2022
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Int J Basic Sci Med. 2022;7: 77-81.
doi: 10.34172/ijbsm.2022.13
  Abstract View: 77
  PDF Download: 57

Original Article

The Effects of 5-Hydroxytryptamine and Interaction With Kisspeptin in Controlling Ghrelin and Adiponectin Secretion

Maryam Kamvar 1 ORCID logo, Fariba Mahmoudi 1* ORCID logo, Fatemeh Mohammadzadeh 1 ORCID logo, Homayoun Khazali 2 ORCID logo, Abolfazl Bayrami 1 ORCID logo

1 Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
2 Department of Animal Science and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
*Corresponding Author: Email: faribamahmoudifm@gmail.com

Abstract

Introduction: 5-Hydroxytryptamine (5HT) and kisspeptin are satiety factors, and ghrelin and adiponectin are orexigenic peptides. In this study, the mediating role of 5HT in the effects of GPR54 receptor blocking on ghrelin and adiponectin secretion was investigated. Methods: Male Wistar rats weighing 220-250 g received saline, kisspeptin 10 (1 or 3 nmol), 5HT (2, 5 or 10 µg), kisspeptin plus 5HT, or peptide 234 (P234) plus 5HT via the third cerebral ventricle. Serum ghrelin and adiponectin concentrations were determined using the enzyme-linked immunosorbent assay method. Results: Kisspeptin or 5HT treatment significantly reduced serum concentrations of ghrelin and adiponectin in comparison with saline. The injection of 2 nmol of P234 + 5HT significantly reduced serum ghrelin concentration compared to the 5HT alone, kisspeptin alone, and kisspeptin + 5HT groups. Injections of either 1 or 2 nmol of P234 along with 5HT significantly declined the mean serum adiponectin level compared to rats received the kisspeptin plus 5HT. Conclusion: Kisspeptin/GPR54 signaling pathway may be a putative target in serotonergic neurons to control ghrelin and adiponectin secretion.
Keywords: 5-hydroxytryptamine, Ghrelin, Adiponectin, Kisspeptin, Peptide 234
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