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Submitted: 21 Jun 2022
Accepted: 20 Dec 2022
ePublished: 29 Dec 2022
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Int J Basic Sci Med. 2022;7: 157-160.
doi: 10.34172/ijbsm.2022.27
  Abstract View: 305
  PDF Download: 192

Brief Report

Effects of Ethanol on Contraction Strength of Chick Neck Striatum Muscle Following Electrical Stimulation of the Nerve

Gholamreza Poorheidari 1,2 ORCID logo, Mahdi Mashhadi Akbar Boojar 1,2* ORCID logo

1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
2 Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
*Corresponding Author: Correspondence to Mahdi Mashhadi Akbar Boojar, Email: , Email: mahdimashhadi@yahoo.com

Abstract

Introduction: Ethanol is a suitable solvent for many in vivo and ex vivo studies. However, it can interfere with normal muscle contraction and make variations in the results. Contrary to the present study, previous investigations revealed the suppressant effect of ethanol on muscle contraction.

Methods: This study was based on an isolated chick biventer cervicis nerve-muscle using the twitch tension recording technique. Nerve and muscle complexes were exposed to several concentrations of ethanol (100, 200, 300, 400, and 500 mM), and impulses were recorded.

Results: Twitch height increased in time and dose-dependent manner, and the concentration of 500 mM of ethanol after 30 minutes revealed the most elevation of muscle impulses.

Conclusion: The potential effects of ethanol on striated muscle contraction are important and should be considered in studies using ethanol as a solvent.

Keywords: Ethanol, Chicken biventer cervices, Striatum muscle contraction

Please cite this article as follows: Poorheidari G, Mashhadi Akbar Boojar M. Effects of ethanol on contraction strength of chick neck striatum muscle following electrical stimulation of the nerve. Int J Basic Sci Med. 2022;7(4):157-160. doi:10.34172/ijbsm.2022.27.
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