Submitted: 16 Oct 2022
Accepted: 26 Oct 2022
ePublished: 29 Mar 2023
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Int J Basic Sci Med. 2023;8: 1-10.
doi: 10.34172/ijbsm.2023.01
  Abstract View: 170
  PDF Download: 82

Original Article

The Protective Effects of Aloe Vera Gel Extract on the Sexual Complications Caused by Diabetes in Male Rats

Hamid Reza Ghaffari 1 ORCID logo, Gholam Reza Bagheri 2 ORCID logo, Bahman Fouladi 3 ORCID logo, Babak Barmaki 4 ORCID logo, Maliheh Alipour Tabrizi 5, Marzieh Poursamimi 6, Javad Poursamimi 7* ORCID logo

1 Department of Basic Sciences, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
2 Department of Nutrition, School of Health, Zabol University of Medical Sciences, Zabol, Iran
3 Department of Parasitology and Mycology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
4 Department of Physiology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
5 School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
6 School of Humanities, Islamic Azad University, Sirjan, Iran
7 Department of Immunology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
*Corresponding Author: Javad Poursamimi, Emails: Javadpoursamimi@ gmail.com, , Email: Poursj1357@zbmu.ac.ir


Introduction: Diabetics usually suffer from chronic complications, including microvascular and macrovascular disorders. The capillaries supplying the sexual organs affect normal sexual functions. The erectile process has been shown to be impaired in diabetics. Vascular damage in diabetics may be associated with decreased testosterone production, sperm count, testicular weight, and seminiferous tubule diameter. In this study, we investigated the effects of Aloe vera gel extract (from Sistan and Baluchistan, Iran) on the male genital system in streptozocin-induced diabetic rats.

Methods: A total of 24 male Wistar rats were included in the study. Diabetes was induced in 12 rats by intraperitoneal injection of a single dose of streptozotocin (STZ). The rats were divided into four groups. The first and third groups received saline (NaCl) by gavage daily. The second and fourth groups received Aloe vera gel extract daily by gavage. Treatments were continued for 30 days. At the end of the treatment period, blood samples were taken and serum glucose and testosterone levels were measured by photometric methods. Histological examinations were performed on the prostate and testes.

Results: Mean weight index, serum levels of glucose and testosterone, mean sperm count, germinal epithelium (GE) thickness, and seminiferous tubule diameter improved significantly in the diabetes+Aloe vera group.

Conclusion: We concluded that consumption of Aloe vera gel extract improved sexual complications in diabetic rats.

Keywords: Type 1 diabetes, Aloe vera gel, Tissue, Sexual tissue, Sexual dysfunctions

Please cite this article as follows: Ghaffari HR, Bagheri GR, Fouladi B, Barmaki B, Alipour Tabrizi M, Poursamimi M, et al. The protective effects of Aloe Vera gel extract on the sexual complications caused by diabetes in male rats. Int J Basic Sci Med. 2023;8(1):1-10. doi:10.34172/ijbsm.2023.01.
First Name
Last Name
Email Address
Security code

Abstract View: 171

Your browser does not support the canvas element.

PDF Download: 82

Your browser does not support the canvas element.