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Submitted: 15 Mar 2023
Accepted: 24 Mar 2023
ePublished: 29 May 2023
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Int J Basic Sci Med. 2023;8: 30-35.
doi: 10.34172/ijbsm.2023.05
  Abstract View: 430
  PDF Download: 183

Original Article

Investigating the Relationship Between High Levels of Angiotensin II in Plasma and the Rate of Deterioration in Hypertensive Patients to COVID-19

Mina Shahnazari 1,2 ORCID logo, Mohammad Mahdi Majzoobi 3 ORCID logo, Fariba Keramat 4 ORCID logo, Younes Mohammadi 5 ORCID logo, Rezvan Najafi 6 ORCID logo, Hamid Reza Ghasemi Basir 4 ORCID logo, Fatemeh Bahrami Banan 2,7 ORCID logo, Akram Jalali 2* ORCID logo

1 Student Research Committee, Hamedan University of Medical Sciences, Hamedan, Iran
2 Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Infectious Diseases, Hamadan University of Medical Sciences & Health Services, Hamadan, Iran
4 Brucellosis Research Center, Department of Infectious Diseases, Hamadan University of Medical Sciences & Health Services, Hamadan, Iran
5 Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
6 Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
7 School of Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding Author: Akram Jalali, Email: aki_jalali@yahoo.com

Abstract

Introduction: The COVID-19 crisis poses a heightened risk to vulnerable populations. Considering factors influencing deterioration, complications, and mortality, it is especially important to pay attention to these groups, including persons with hypertension (HTN) and diabetes. This study aimed to investigate the correlation between the angiotensin II (ANG II) level and the disease severity and clinical course in COVID-19 patients.

Methods: A cross-sectional study was conducted on 50 COVID-19 patients (mean age 59.1±20) admitted to Sinai hospital in Hamedan. The blood samples of the patients were taken during hospitalization and discharge, and the plasma ANG II level was measured using an enzyme-linked immunosorbent assay kit. The quantitative comparison was analyzed with paired t test and qualitative comparison with the chi-square test. The correlation of variables was checked with the Pearson test, and P<0.05 was considered statistically significant.

Results: Overall, 44%, 16%, and 10% of COVID-19 patients had HTN, cardiovascular disease (CVD), and 10% diabetes, respectively. The oxygen level of 82% of the patients was below 90, of which 68% were intubated, and the lowest oxygen levels were observed in patients with HTN and CVD with 2 deaths. The primary and secondary examination of the ANG II level demonstrated that its level was significantly higher during illness compared to full recovery and decreased during recovery.

Conclusion: The ANG II level is related to the severity of the disease in the early stages of 2019- nCoV infection. Therefore, HTN or other diseases that affect the level of ANG II in the blood can increase the severity of the disease.

Keywords: Angiotensin-converting enzyme 2, Angiotensin II, COVID-19, Hypertension

Please cite this article as follows: Shahnazari M, Majzoobi MM, Keramat F, Mohammadi Y, Najafi R, Ghasemi Basir HR, et al. Investigating the relationship between high levels of angiotensin ii in plasma and the rate of deterioration in hypertensive patients to COVID-19. Int J Basic Sci Med. 2023;8(1):30-35. doi:10.34172/ijbsm.2023.05.
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